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Summary: In the absence of targetable hormonal axes, chemoresistance for triple-negative breast cancer (TNBC) often compromises patient outcomes.To investigate the 1073spx underlying tumor dynamics, we performed trajectory analysis on the single-nuclei RNA-seq (snRNA-seq) of chemoresistant tumor clones during neoadjuvant chemotherapy (NAC).It revea
The most debated phenomena of the 21st century which might change the global landscape for living organisms.The samephenomena could even threaten climate pattern.Because of this, the earth may experience a highly unstable natural disasterlike flooding, cyclone, earthquake, tsunami, severe drought and inhabitant environment like the highly polluted
BackgroundObservational investigations have indicated a notable correlation between body mass index (BMI) and breast cancer (BC).Nevertheless, the precise biological pathways driving this correlation remain ambiguous.Consequently, we utilized Mendelian randomization (MR) techniques to explore the causative link between BMI and genetic predispositio